MPTP Poisoning

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Also Known As:

MPTP-Induced Degeneration of the Striatum; MPTP-Induced Parkinsonism; Neurotoxicity Syndrome, MPTP; Poisoning, 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine; MPTP Induced Degeneration of the Striatum; MPTP Induced Parkinsonism; MPTP Neurotoxicity Syndromes; Neurotoxicity Syndromes, MPTP; Parkinsonism, MPTP-Induced; Poisoning, MPTP; MPTP Neurotoxicity Syndrome

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Basal Ganglia Diseases: 346
      - Parkinsonian Disorders: 9203
        Secondary Parkinson Disease: 69
        MPTP Poisoning: 192
  - Movement Disorders: 4634
    - Parkinsonian Disorders: 9203
      - Secondary Parkinson Disease: 69
        MPTP Poisoning: 192
- Neurotoxicity Syndromes: 299
  - MPTP Poisoning: 192
Chemically-Induced Disorders: 2
- Poisoning: 39310
  - Neurotoxicity Syndromes: 299
    - MPTP Poisoning: 192

M L Cornfeldt Selected Research

M L Cornfeldt Research Topics

Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure